Volume 1 Issue 1
Neuron-Microglia Communication Delivered CRFR1 Phosphorylation during Long-Term Morphine Treatment
Hui Zhao*, Han-Wei Huang, Gen-Cheng Wu
Morphine-mediated AC activation requires Src kinase, which was postulated to be responsible for morphine tolerance and dependence. Currently, we demonstrated that following long-term morphine treatment and subsequent naloxone precipitation, microglia was activated, which appeared to be obligatory for CD44 expression and production of IL-1beta, iNOS, MCP-1, MIP-1alpha, MIP-1beta, and TNF-alpha. Significantly, neuronal CRFR1 could be phosphorylated at serine 396 by c-Src-RSK1 signaling, which was subjected to microglia activation and preferentially strengthened AC5 up-regulation.
Pyrimidine Derivative Compounds as HSP90 Inhibitors in Cancer Treatment
Pyrimidine scaffold is an important member of bioactive heterocyclic compounds which are also used in the treatment of cancer, infection diseases, diabetes, gastrointestinal diseases, and cardiovascular diseases. Therefore, pyrimidine ring has been significant structure for synthetic organic chemists and drug designers for many years. Pyrimidine derivatives interact with a large number of intracellular targets in human. Especially, pyrimidine derivative compounds inhibit Heat Shock Protein 90 (Hsp90) chaperone activity, and interrupt proliferation in cancer cell.
Acute Ingestions of Acetaminophen Combination Products Resulting in Marked Bactrian Pharmacokinetics
Jean CY Lo*, Stephen Thornton, Richard F. Clark
Acetaminophen (APAP) is a widely available analgesic and antipyretic that is presented in numerous over the counter and prescription preparations, frequently as part of a combination product with an antihistamine or an opioid. The ubiquity of acetaminophen-containing products explains why it is among the most commonly encountered substances involved in overdoses reported to the AAPCC’s National Poison Data System.
Target Specific Cancer Treatment with Carbon Monoxide Releasing Molecules
Carbon monoxide (CO) is a colorless, odorless, and tasteless gas which has been defined as “silent killer” for a long time. CO has strong affinity for hemoglobin, and CO-hemoglobin (carboxyhemoglobin) complex inhibits oxygen delivery to tissues by red blood cells. Apart from this poisoner effect, the therapeutic potential of CO has been extensively evaluated in pathogenesis of many diseases.
Adriamycin’s Hepatotoxic Effect Associated With Local Renin Angiotensin System
Celal GUVEN*, Eylem TASKIN
Cancer patient’s number is going to scale up every year. Adriamycin (ADR) is one of the most effective anticancer drug against to solid tumors. Unfortunately, the drug has a undesired side effect on some tissue including heart, liver, kidney, pancreas. Although many studies found that ADR’s toxic effect relate to oxidative stress, the exact molecular mechanisms underlying of its side effect has not completely understood. There is limited study researched the relationship between liver exposed to ADR and local renin-angiotensin system (RAS) in the liver.